Large-scale GMP exosome and microvesicle production
from human cells, animal cells, milk, plants.
HUMAN: skin fibroblasts, keratinocytes, adipocytes; blood monocytes, macrophages; microglia; bronchial epithelium; vein, capillary endothelium; colon epithelium; mesenchymal stem cells; cancer cells (melanoma, glioblastoma, colon carcinoma); retinal neuroepithelium, custom.
ANIMAL: mesenchymal stem cells, glial cells, cardiomyocytes.
MILK, COLOSTRUM: bovine, goat’s milk and bovine colostrum.
PLANTS such as hemp, medicinal herbs, fruits, vegetables, berries, and other plant material.
Targeting tag attachment, cargo loading.
BIOACTIVE CARGO LOADING, stabilizing, attachment, and controlled release protocol development.
EXOSOME TARGETING for specific cells and organelles by surface peptide tags.
LARGE-SCALE PRODUCTION of engineered exosomes.
GLP preclinical development
MODELS AND ASSAYS: myocardial ischemia, cerebral ischemia, neuroinflammation, Alzheimer’s disease, cancer, osteogenesis, in vitro barrier permeability (blood-brain, intestinal, vascular endothelial, airway epithelial), bacterial and viral inflammation, regenerative activity on selected tissue, mitochondrial and glycolytic activity, oxidation stress and antioxidant efficiency studies, custom study design.
EV ISOLATION AND CHARACTERIZATION FOR BIOMARKER RESEARCH.
ISOLATION of different extracellular vesicle and particle fractions from biofluids: exomeres/supermeres, exosomes, microvesicles, apoptotic bodies, endosomes.
CHARACTERIZATION of extracellular vesicles and particles for number, size, protein, nucleic acid content, biomarker, and cargo assessment.
What are exosomes
Exosomes are lipid bilayer-enclosed nanovesicles produced by cells serving as cell-to cell delivery vehicles. They are formed from intracellular membrane compartments during endosomal maturation process and released to extracellular space from the multivesicular body.
Most of the cells secrete exosomes, which can be found in all body fluids: blood, liquid, saliva, synovial fluid, etc.
Kaunas, Lithuania Corp. ID 305464858
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